Examining Cocaine Conditioning Place Preference in Mice
نویسندگان
چکیده
منابع مشابه
mGluR5 Knockout mice exhibit normal conditioned place-preference to cocaine
Metabotropic glutamate receptor 5 (mGluR5) null mutant (-/-) mice have been reported to totally lack the reinforcing or locomotor stimulating effects of cocaine. We tested mGluR5 -/and +/+ mice for their locomotor and conditioned placepreference response to cocaine. Unlike the previous finding, here we show that compared to mGluR5 +/+ mice, -/mice exhibit no difference in the locomotor response...
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Recently, Spyraki et al. (Brain Research, 253 (1982) 195-203) reported that cocaine-induced place preference conditioning was unaffected by blockade of central dopamine (DA) or norepinephrine function. In addition, systemic injections of the local anesthetic procaine produced place preference conditioning. The present study was undertaken to further evaluate the possible role of DA in cocaine-i...
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Traditional models of drug-seeking behavior have shown that exposure to associated environmental cues can trigger relapse. These learned associations take place during repeated drug administration, resulting in conditioned reinforcement. Although considerable investigation has occurred regarding simple conditioned stimuli, less is known about complex environmental cues, particularly those that ...
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UNLABELLED Recently, it was shown that D-cycloserine (DCS, a NMDA partial agonist) facilitated extinction of fear as well as cocaine conditioned place preference (CPP) in rats. METHODS The present study examined the effects of DCS (15 mg/kg i.p. and 30 mg/kg i.p.) on extinction and renewal of cocaine-induced CPP in C57bL/c mice. In parallel, we examined the effects of DCS on locomotor activit...
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ژورنال
عنوان ژورنال: BIO-PROTOCOL
سال: 2020
ISSN: 2331-8325
DOI: 10.21769/bioprotoc.3595